From the archive, originally posted by: [ spectre ]

http://en.wikipedia.org/wiki/Synesthesia

NEUROPLASTICITY
http://www.wired.com/wired/archive/15.04/esp.html

Mixed Feelings

See with your tongue. Navigate with your skin. Fly by the seat of your
pants (literally). How researchers can tap the plasticity of the brain
to hack our 5 senses – and build a few new ones.

By Sunny Bains

For six weird weeks in the fall of 2004, Udo Wächter had an unerring
sense of direction. Every morning after he got out of the shower,
Wächter, a sysadmin at the University of Osnabrück in Germany, put on
a wide beige belt lined with 13 vibrating pads – the same weight-and-
gear modules that make a cell phone judder. On the outside of the belt
were a power supply and a sensor that detected Earth’s magnetic field.
Whichever buzzer was pointing north would go off. Constantly.

“It was slightly strange at first,” Wächter says, “though on the bike,
it was great.” He started to become more aware of the peregrinations
he had to make while trying to reach a destination. “I finally
understood just how much roads actually wind,” he says. He learned to
deal with the stares he got in the library, his belt humming like a
distant chain saw. Deep into the experiment, Wächter says, “I suddenly
realized that my perception had shifted. I had some kind of internal
map of the city in my head. I could always find my way home.
Eventually, I felt I couldn’t get lost, even in a completely new
place.”

The effects of the “feelSpace belt” – as its inventor, Osnabrück
cognitive scientist Peter König, dubbed the device – became even more
profound over time. König says while he wore it he was “intuitively
aware of the direction of my home or my office. I’d be waiting in line
in the cafeteria and spontaneously think: I live over there.” On a
visit to Hamburg, about 100 miles away, he noticed that he was
conscious of the direction of his hometown. Wächter felt the vibration
in his dreams, moving around his waist, just like when he was awake.

Direction isn’t something humans can detect innately. Some birds can,
of course, and for them it’s no less important than taste or smell are
for us. In fact, lots of animals have cool, “extra” senses. Sunfish
see polarized light. Loggerhead turtles feel Earth’s magnetic field.
Bonnethead sharks detect subtle changes (less than a nanovolt) in
small electrical fields. And other critters have heightened versions
of familiar senses – bats hear frequencies outside our auditory range,
and some insects see ultraviolet light.

We humans get just the five. But why? Can our senses be modified?
Expanded? Given the right prosthetics, could we feel electromagnetic
fields or hear ultrasound? The answers to these questions, according
to researchers at a handful of labs around the world, appear to be
yes.

It turns out that the tricky bit isn’t the sensing. The world is full
of gadgets that detect things humans cannot. The hard part is
processing the input. Neuroscientists don’t know enough about how the
brain interprets data. The science of plugging things directly into
the brain – artificial retinas or cochlear implants – remains
primitive.

So here’s the solution: Figure out how to change the sensory data you
want – the electromagnetic fields, the ultrasound, the infrared – into
something that the human brain is already wired to accept, like touch
or sight. The brain, it turns out, is dramatically more flexible than
anyone previously thought, as if we had unused sensory ports just
waiting for the right plug-ins. Now it’s time to build them.

How do we sense the world around us? It seems like a simple question.
Eyes collect photons of certain wavelengths, transduce them into
electrical signals, and send them to the brain. Ears do the same thing
with vibrations in the air – sound waves. Touch receptors pick up
pressure, heat, cold, pain. Smell: chemicals contacting receptors
inside the nose. Taste: buds of cells on the tongue.

There’s a reasonably well-accepted sixth sense (or fifth and a half,
at least) called proprioception. A network of nerves, in conjunction
with the inner ear, tells the brain where the body and all its parts
are and how they’re oriented. This is how you know when you’re upside
down, or how you can tell the car you’re riding in is turning, even
with your eyes closed.

When computers sense the world, they do it in largely the same way we
do. They have some kind of peripheral sensor, built to pick up
radiation, let’s say, or sound, or chemicals. The sensor is connected
to a transducer that can change analog data about the world into
electrons, bits, a digital form that computers can understand – like
recording live music onto a CD. The transducer then pipes the
converted data into the computer.

But before all that happens, programmers and engineers make decisions
about what data is important and what isn’t. They know the bandwidth
and the data rate the transducer and computer are capable of, and they
constrain the sensor to provide only the most relevant information.
The computer can “see” only what it’s been told to look for.

The brain, by contrast, has to integrate all kinds of information from
all five and a half senses all the time, and then generate a complete
picture of the world. So it’s constantly making decisions about what
to pay attention to, what to generalize or approximate, and what to
ignore. In other words, it’s flexible.

In February, for example, a team of German researchers confirmed that
the auditory cortex of macaques can process visual information.
Similarly, our visual cortex can accommodate all sorts of altered
data. More than 50 years ago, Austrian researcher Ivo Kohler gave
people goggles that severely distorted their vision: The lenses turned
the world upside down. After several weeks, subjects adjusted – their
vision was still tweaked, but their brains were processing the images
so they’d appear normal. In fact, when people took the glasses off at
the end of the trial, everything seemed to move and distort in the
opposite way.

Later, in the ’60s and ’70s, Harvard neuro biologists David Hubel and
Torsten Wiesel figured out that visual input at a certain critical age
helps animals develop a functioning visual cortex (the pair shared a
1981 Nobel Prize for their work). But it wasn’t until the late ’90s
that researchers realized the adult brain was just as changeable, that
it could redeploy neurons by forming new synapses, remapping itself.
That property is called neuroplasticity.

This is really good news for people building sensory prosthetics,
because it means that the brain can change how it interprets
information from a particular sense, or take information from one
sense and interpret it with another. In other words, you can use
whatever sensor you want, as long as you convert the data it collects
into a form the human brain can absorb.

Paul Bach-y-Rita built his first “tactile display” in the 1960s.
Inspired by the plasticity he saw in his father as the older man
recovered from a stroke, Bach-y-Rita wanted to prove that the brain
could assimilate disparate types of information. So he installed a 20-
by-20 array of metal rods in the back of an old dentist chair. The
ends of the rods were the pixels – people sitting in the chairs could
identify, with great accuracy, “pictures” poked into their backs; they
could, in effect, see the images with their sense of touch.

By the 1980s, Bach-y-Rita’s team of neuroscientists – now located at
the University of Wisconsin – were working on a much more
sophisticated version of the chair. Bach-y-Rita died last November,
but his lab and the company he cofounded, Wicab, are still using touch
to carry new sensory information. Having long ago abandoned the
vaguely Marathon Man like dentist chair, the team now uses a
mouthpiece studded with 144 tiny electrodes. It’s attached by ribbon
cable to a pulse generator that induces electric current against the
tongue. (As a sensing organ, the tongue has a lot going for it: nerves
and touch receptors packed close together and bathed in a conducting
liquid, saliva.)

So what kind of information could they pipe in? Mitch Tyler, one of
Bach-y-Rita’s closest research colleagues, literally stumbled upon the
answer in 2000, when he got an inner ear infection. If you’ve had one
of these (or a hangover), you know the feeling: Tyler’s world was
spinning. His semicircular canals – where the inner ear senses
orientation in space – weren’t working. “It was hell,” he says. “I
could stay upright only by fixating on distant objects.” Struggling
into work one day, he realized that the tongue display might be able
to help.

The team attached an accelerometer to the pulse generator, which they
programmed to produce a tiny square. Stay upright and you feel the
square in the center of your tongue; move to the right or left and the
square moves in that direction, too. In this setup, the accelerometer
is the sensor and the combination of mouthpiece and tongue is the
transducer, the doorway into the brain.

The researchers started testing the device on people with damaged
inner ears. Not only did it restore their balance (presumably by
giving them a data feed that was cleaner than the one coming from
their semi circular canals) but the effects lasted even after they’d
removed the mouthpiece – sometimes for hours or days.

The success of that balance therapy, now in clinical trials, led Wicab
researchers to start thinking about other kinds of data they could
pipe to the mouthpiece. During a long brainstorm session, they
wondered whether the tongue could actually augment sight for the
visually impaired. I tried the prototype; in a white-walled office
strewn with spare electronics parts, Wicab neuroscientist Aimee
Arnoldussen hung a plastic box the size of a brick around my neck and
gave me the mouthpiece. “Some people hold it still, and some keep it
moving like a lollipop,” she said. “It’s up to you.”

Arnoldussen handed me a pair of blacked-out glasses with a tiny camera
attached to the bridge. The camera was cabled to a laptop that would
relay images to the mouthpiece. The look was pretty geeky, but the
folks at the lab were used to it.

She turned it on. Nothing happened.

“Those buttons on the box?” she said. “They’re like the volume
controls for the image. You want to turn it up as high as you’re
comfortable.”

I cranked up the voltage of the electric shocks to my tongue. It
didn’t feel bad, actually – like licking the leads on a really weak 9-
volt battery. Arnoldussen handed me a long white foam cylinder and
spun my chair toward a large black rectangle painted on the wall.
“Move the foam against the black to see how it feels,” she said.

I could see it. Feel it. Whatever – I could tell where the foam was.
With Arnoldussen behind me carrying the laptop, I walked around the
Wicab offices. I managed to avoid most walls and desks, scanning my
head from side to side slowly to give myself a wider field of view,
like radar. Thinking back on it, I don’t remember the feeling of the
electrodes on my tongue at all during my walkabout. What I remember
are pictures: high-contrast images of cubicle walls and office doors,
as though I’d seen them with my eyes. Tyler’s group hasn’t done the
brain imaging studies to figure out why this is so – they don’t know
whether my visual cortex was processing the information from my tongue
or whether some other region was doing the work.

I later tried another version of the technology meant for divers. It
displayed a set of directional glyphs on my tongue intended to tell
them which way to swim. A flashing triangle on the right would mean
“turn right,” vertical bars moving right says “float right but keep
going straight,” and so on. At the University of Wisconsin lab, Tyler
set me up with the prototype, a joystick, and a computer screen
depicting a rudimentary maze. After a minute of bumping against the
virtual walls, I asked Tyler to hide the maze window, closed my eyes,
and successfully navigated two courses in 15 minutes. It was like I
had something in my head magically telling me which way to go.

In the 1970s, the story goes, a Navy flight surgeon named Angus Rupert
went skydiving nude. And on his way down, in (very) free fall, he
realized that with his eyes closed, the only way he could tell he was
plummeting toward earth was from the feel of the wind against his skin
(well, that and the flopping). He couldn’t sense gravity at all.

The experience gave Rupert the idea for the Tactical Situational
Awareness System, a suitably macho name for a vest loaded with
vibration elements, much like the feelSpace belt. But the TSAS doesn’t
tell you which way is north; it tells you which way is down.

In an airplane, the human proprioceptive system gets easily confused.
A 1-g turn could set the plane perpendicular to the ground but still
feel like straight and level flight. On a clear day, visual cues let
the pilot’s brain correct for errors. But in the dark, a pilot who
misreads the plane’s instruments can end up in a death spiral. Between
1990 and 2004, 11 percent of US Air Force crashes – and almost a
quarter of crashes at night – resulted from spatial disorientation.

TSAS technology might fix that problem. At the University of Iowa’s
Operator Performance Laboratory, actually a hangar at a little
airfield in Iowa City, director Tom Schnell showed me the next-
generation garment, the Spatial Orientation Enhancement System.

First we set a baseline. Schnell sat me down in front of OPL’s
elaborate flight simulator and had me fly a couple of missions over
some virtual mountains, trying to follow a “path” in the sky. I was
awful – I kept oversteering. Eventually, I hit a mountain.

Then he brought out his SOES, a mesh of hard-shell plastic, elastic,
and Velcro that fit over my arms and torso, strung with vibrating
elements called tactile stimulators, or tactors. “The legs aren’t
working,” Schnell said, “but they never helped much anyway.”

Flight became intuitive. When the plane tilted to the right, my right
wrist started to vibrate – then the elbow, and then the shoulder as
the bank sharpened. It was like my arm was getting deeper and deeper
into something. To level off, I just moved the joystick until the
buzzing stopped. I closed my eyes so I could ignore the screen.

Finally, Schnell set the simulator to put the plane into a dive. Even
with my eyes open, he said, the screen wouldn’t help me because the
visual cues were poor. But with the vest, I never lost track of the
plane’s orientation. I almost stopped noticing the buzzing on my arms
and chest; I simply knew where I was, how I was moving. I pulled the
plane out.

When the original feelSpace experiment ended, Wächter, the sysadmin
who started dreaming in north, says he felt lost; like the people
wearing the weird goggles in those Austrian experiments, his brain had
remapped in expectation of the new input. “Sometimes I would even get
a phantom buzzing.” He bought himself a GPS unit, which today he
glances at obsessively. One woman was so dizzy and disoriented for her
first two post-feelSpace days that her colleagues wanted to send her
home from work. “My living space shrank quickly,” says König. “The
world appeared smaller and more chaotic.”

I wore a feelSpace belt for just a day or so, not long enough to have
my brain remapped. In fact, my biggest worry was that as a dark-
complexioned person wearing a wide belt bristling with wires and
batteries, I’d be mistaken for a suicide bomber in charming downtown
Osnabrück.

The puzzling reactions of the longtime feelSpace wearers are
characteristic of the problems researchers are bumping into as they
play in the brain’s cross-modal spaces. Nobody has done the imaging
studies yet; the areas that integrate the senses are still unmapped.

Success is still a long way off. The current incarnations of sensory
prosthetics are bulky and low-resolution – largely impractical. What
the researchers working on this technology are looking for is
something transparent, something that users can (safely) forget
they’re wearing. But sensor technology isn’t the main problem. The
trick will be to finally understand more about how the brain processes
the information, even while seeing the world with many different kinds
of eyes.

{Sunny Bains (www.sunnybains.com/blog) wrote about self-repairing
micromachines in issue 13.09.}